Interaction of negative valence system and cognitive system

C01: Gene-environment interactions and the role of impulsivity in responding to acute threats: early life stress and escalated aggression in recombinant inbred mouse strains

Aet O'Leary David Slattery Goethe University Frankfurt Interaction of negative valence system and cognitive system Biological Psychiatry

Sex-dependent effects and gene-environment interactions will be investigated by applying escalating aggression paradigms.

C02: Aggressive decisions in social conflicts: Neuro-cognitive models for healthy individuals and psychiatric patients with high scores of aggression

Christoph Korn Klaus Mathiak RWTH Aachen Heidelberg University Interaction of negative valence system and cognitive system Biological Psychology and Cognitive Neuroscience Cognitive, Systems and Behavioural Neurobiolog Human Cognitive and Systems Neuroscience Biological Psychiatry

Develop virtual scenarios to assess decision strategies in cartoon-like and naturalistic contexts.

C03: Distributed network control and interventions to frustrative non-reward and threat triggered aggressions

Wolfgang Kelsch Wolfgang Weber-Fahr Johannes Gutenberg University Mainz Central Institute of Mental Health Interaction of negative valence system and cognitive system Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Investigate context-dependent aggression triggered by frustrative non-reward or acute social threats.

C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression

Christine Margarete Freitag Andreas Chiocchetti Goethe University Frankfurt Interaction of negative valence system and cognitive system Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Address sex-specific NVS (reactive aggression) and CS (different dimensions of psychopathy, proactive aggression) associated risk factors, and risk factor-based biosignatures.

C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems

Christine Ecker Goethe University Frankfurt Interaction of negative valence system and cognitive system Biological Psychiatry

Link questionnaire measures of aggression to specific neural substrates using structural MRI.

C06: Brain mechanisms differentiating aggressive vs. non-aggressive psychopathology as sequelae of early life maltreatment

Sabine Herpertz Corinne Neukel Heidelberg University Interaction of negative valence system and cognitive system Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Identify specific neuronal mechanisms related to the NVS and CS in female and male clinical samples with a history of early-life maltreatment (ELM) who exhibit externalizing, aggressive psychopathologies as opposed to internalizing, non-aggressive psychopathologies.

C07: Identifying mediators of threat-aggression and experimental manipulation by tDCS

Michael Plichta Wolfgang Retz Goethe University Frankfurt Johannes Gutenberg University Mainz Interaction of negative valence system and cognitive system Biological Psychiatry

Test the interaction of the CS and frustrative non-reward as part of the NVS.

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