NEUROPSYCHOBIOLOGY
OF AGGRESSION

A Transdiagnostic Approach
in Mental Disorders

Aggression in mental disorders is highly prevalent and carries severe consequences for individuals and society. However, its diverse manifestations and complex causes are still poorly understood, as traditional research often focuses on isolated diagnoses.

The TRR 379 addresses this challenge by shifting the focus to cross-disorder „biosignatures“. By integrating multidimensional biological and behavioral profiles, we investigate the underlying mechanisms of aggression beyond traditional diagnostic boundaries. Our goal is to build a comprehensive, integrative model that enables more precise prevention and targeted therapeutic interventions.

Objectives

RDoC Domains

This Transregional Collaborative Research Center 379 (TRR) will follow the Research Domain Criteria (RDoC) framework, investigating aggression in a transdiagnostic manner. Within the RDoC's "negative valence system" (NVS) and "cognitive system" (CS) the TRR aims to identify and characterize specific biosignatures and predict aggressive behavior.

Multidimensional scale

The TRR will seek to identify and define these mechanisms on a multilevel scale, advancing a detailed understanding of the biology, psychology, and physiology of specific aggressive biosignatures across mental disorders.

→ All Research Topics

From Early Adolescence until Adulthood

Finally, the TRR aims to address the temporal stability of AMD and the (dys-)functional NVS and CS during development from early adolescence until adulthood and during the disease course.

Area A Projects on
Negative Valence

Area B Projects on
Cognitive Control

Area C Projects on the
Interaction of A & C

Z: Central Service Central Service Projects