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C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems

Link questionnaire measures of aggression to specific neural substrates using structural MRI. The resulting patterns of aggression-related neuroanatomical variability will be co- registered with the Allen Human Brain Atlas providing gene-expression data, to highlight genes with a spatial pattern of expression that matches the neuroimaging findings. Utilizing the neurotypical control data, a normative model of neuroanatomical diversity within the NVS and CS will be established to quantify neuroanatomical abnormalities within these systems in individual cases

Contributors

Christine Ecker

C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems Q02: Data management for computational modelling Principal investigator Research data committee member Goethe University Frankfurt
Christine Ecker is a professor at Goethe University Frankfurt, specializing in clinical neuroscience and psychiatry. Her research focuses on the neurobiological underpinnings of autism spectrum disorders and other neurodevelopmental conditions, utilizing advanced neuroimaging techniques.

Publications

Evaluating analytic strategies to obtain high-resolution, vertex-level measures of cortical neuroanatomy in children in low- and middle-income countries

Christine Ecker C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems
High-field magnetic resonance imaging to explore brain structure and function remains limited to high-resource settings. Novel, low-field (<0.1 T) imaging offers a more cost-effective/accessible alternative. However, the validity of low-field data at spatial resolutions relevant to research and clinic (vertex-level) remains unclear.

Parsing Autism Heterogeneity: Transcriptomic Subgrouping of Imaging-Derived Phenotypes in Autism

Andreas G Chiocchetti Tobias Banaschewski Christine Ecker B05: Predictors and (neuro-)biological correlates of (cyber-)bullying and victimization in real-life contexts C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression
Neurodevelopmental conditions, such as autism, are highly heterogeneous at both the mechanistic and phenotypic levels. Therefore, parsing heterogeneity is vital for uncovering underlying processes that could inform the development of targeted, personalized support.