C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression

Address sex-specific NVS (reactive aggression) and CS (different dimensions of psychopathy, proactive aggression) associated risk factors, and risk factor-based biosignatures in young people. Considering the interacting genetic, environmental, and hormonal factors related to these specific aggressive behavior dimensions, C04 will identify specific and shared factors and mechanisms related to NVS and CS in female and male youth with and without pathological aggression. Implementing deep-learning algorithms, sex-specific, data-driven subgroups in relation to dimensions of aggressive behavior will be described and probed against the NVS and CS. Group-level risk factors of aggressive behavior dimensions, and individual risk factor-based subgrouping will be the basis of developing a biologically informed stratification strategy for tailored treatment. Models and classifiers will be established cross-sectionally in available data and replicated in the prospectively collected cross-sectional data (Q01). In addition, C04 will test the models and classifiers for predictive validity in the longitudinal data of the TRR Q01 cohort.

Contributors

Andreas G Chiocchetti

C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression Principal investigator Equal opportunity committee member Goethe University Frankfurt

Professor Andreas G Chiocchetti is passionate about working with models to understand human behaviour and neurodiversity. Biotechnologist by training (Salzburg, Austria), Phd in Genetics, Research Fellow at UCLA, Los Angeles, ex Data-Scientist in Industry.

Christine Margarete Freitag

C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span Principal investigator Goethe University Frankfurt

Professor Christine M Freitag focuses on Translational research in Neurodevelopmental, Anxiety and Disruptive Behavior Disorders in children and youth. Her methods comprise biostatistics, diagnostic and biomarker studies, randomized-controlled trials (phase-IIa, phase-III), brain stimulation and behavioural/psychotherapeutic interventions.

Publications

Parsing Autism Heterogeneity: Transcriptomic Subgrouping of Imaging-Derived Phenotypes in Autism

Andreas G Chiocchetti Tobias Banaschewski Christine Ecker B05: Predictors and (neuro-)biological correlates of (cyber-)bullying and victimization in real-life contexts C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression

Neurodevelopmental conditions, such as autism, are highly heterogeneous at both the mechanistic and phenotypic levels. Therefore, parsing heterogeneity is vital for uncovering underlying processes that could inform the development of targeted, personalized support.