Central Institute of Mental Health

Contributors

Tobias Banaschewski

B05: Predictors and (neuro-)biological correlates of (cyber-)bullying and victimization in real-life contexts Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span Q03: Integrated Research Training Group (RTG) Principal investigator Research training group (RTG) committee member Central Institute of Mental Health Heidelberg University

Medical Director of the Clinic for Child and Adolescent Psychiatry and Psychotherapy and Deputy Director of the Central Institute of Mental Health.

Gabriele Ende

A03: Modulation of aggression by acute threat A08: The metabolic lung-brain axis in aggressive behavior in patients with AMD Q02: Data management for computational modelling Principal investigator Research data committee member Quality control group member Heidelberg University Central Institute of Mental Health

Gabriele Ende is a researcher associated with the Central Institute of Mental Health (ZI) in Mannheim, Germany. Her work primarily focuses on neuroimaging and the application of magnetic resonance spectroscopy (MRS) in psychiatric and neurological disorders.

Nathalie Holz

B05: Predictors and (neuro-)biological correlates of (cyber-)bullying and victimization in real-life contexts Principal investigator Central Institute of Mental Health Heidelberg University

Nathalie Holz is leader of the research group Developmental neuroscience in psychiatry at the ZI Mannheim.

Andreas Meyer-Lindenberg

A05: Peripersonal space violations and social threat: daily-life psychological and neural mechanisms of environmental risk for reactive aggression A06: Decoding dynamic reciprocal neural mechanism underlying reactive aggression: Insights from fMRI and fNIRS hyperscanning B04: Investigating psychological and neural correlates of intimate partner violence Principal investigator Central Institute of Mental Health Heidelberg University

Andreas Meyer-Lindenberg is a distinguished psychiatrist and neuroscientist based in Germany, renowned for his groundbreaking research on the neurobiological underpinnings of psychiatric disorders. He serves as the Director of the Central Institute of Mental Health (ZI) in Mannheim and is a professor at the University of Heidelberg.

Richard Nkrumah

Q02: Data management for computational modelling Doctoral Researcher Central Institute of Mental Health

Christian Paret

B03: A process-based brain-computer interface to modulate aggressive behavior – a real-time fMRI neurofeedback study Principal investigator Central Institute of Mental Health Heidelberg University

Research group leader, research assistant

Christian Schmahl

A03: Modulation of aggression by acute threat Principal investigator Citizen Advisory Boad Central Institute of Mental Health Heidelberg University

Heike Tost

A05: Peripersonal space violations and social threat: daily-life psychological and neural mechanisms of environmental risk for reactive aggression Principal investigator Central Institute of Mental Health Heidelberg University

Wolfgang Weber-Fahr

C03: Distributed network control and interventions to frustrative non-reward and threat triggered aggressions Principal investigator Central Institute of Mental Health Heidelberg University

Projects

A03: Modulation of aggression by acute threat

Gabriele Ende Christian Schmahl Central Institute of Mental Health Negative valence system Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

The neural and neurochemical patterns of acute threat as modulators of aggression in BPD will be investigated in this project. The modulation of aggressive responses under acute threat is induced by the threat-of-shock paradigm.

A05: Peripersonal space violations and social threat: daily-life psychological and neural mechanisms of environmental risk for reactive aggression

Heike Tost Andreas Meyer-Lindenberg Central Institute of Mental Health Negative valence system Human Cognitive and Systems Neuroscience Biological Psychiatry

Peripersonal space, the representation of the space immediately surrounding the body, will be studied as an underlying factor for threat experience. Early-life stressors and daily-life stressors will be tested as factors influencing PPS processing and associated specific brain activation patterns.

A06: Decoding dynamic reciprocal neural mechanism underlying reactive aggression: Insights from fMRI and fNIRS hyperscanning

Kerstin Konrad Andreas Meyer-Lindenberg Vanessa Reindl RWTH Aachen Central Institute of Mental Health Negative valence system Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

The project employs fMRI and functional near-infrared spectroscopy (fNIRS) hyperscanning techniques to explore how brain-to-brain synchrony and dynamic processes within peer dyads facilitate or inhibit aggressive behavior under diverse levels of provocation in adolescent patients and controls.

A08: The metabolic lung-brain axis in aggressive behavior in patients with AMD

Thomas Frodl David Slattery Gabriele Ende RWTH Aachen Goethe University Frankfurt Central Institute of Mental Health Negative valence system Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Beta-hydroxy-butyrate (BHB), a ketone body, is negatively associated with aggressive behavior. BHB is a metabolite and an active signaling substrate involved in epigenetic regulation of e.g., neurotrophic factor genes in the brain.

B03: A process-based brain-computer interface to modulate aggressive behavior – a real-time fMRI neurofeedback study

Klaus Mathiak Christian Paret Jana Zweerings RWTH Aachen Central Institute of Mental Health Cognitive system Biological Psychiatry

Probe the self-regulation of CS networks in adults and adolescents diagnosed with mental disorders related to frequent stress-associated affective outbursts and aggressive symptoms in posttraumatic stress disorder (PTSD), and BPD.

B04: Investigating psychological and neural correlates of intimate partner violence

Lisa Wagels Andreas Meyer-Lindenberg Katja Bertsch Julia Koch Julia Schräder Linda Wilkin-Krug RWTH Aachen Central Institute of Mental Health Julius-Maximilians University Würzburg Cognitive system Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Focus on the neural correlates of characterizing cognitive control deficits during conflict situations. The project will investigate patients with varying levels of cognitive control along with their close partners (sibling or intimate partner) to identify the dynamics of self-regulation and co-regulation in provoked conflict situations in patients with control deficits.

B05: Predictors and (neuro-)biological correlates of (cyber-)bullying and victimization in real-life contexts

Nathalie Holz Tobias Banaschewski Central Institute of Mental Health Cognitive system Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Focus on the investigation of a lack of cognitive control in bullies and victims that contributes to the risk of developing mental health problems. Therefore, the project will assess bullies and their victims in real-life and digital social interactions to investigate how aberrant cognitive and affective prefrontal control and sensitivity to peer rejection with accompanied alterations in autonomic arousal may increase externalizing and internalizing behavior.

C03: Distributed network control and interventions to frustrative non-reward and threat triggered aggressions

Wolfgang Kelsch Wolfgang Weber-Fahr Johannes Gutenberg University Mainz Central Institute of Mental Health Interaction of negative valence system and cognitive system Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Investigate context-dependent aggression triggered by frustrative non-reward or acute social threats. Using newly developed approaches, multiple behavioral domains will be assessed in a semi-naturalistic, autonomous mouse habitat. Specifically, the habitat assesses the inter-individual dynamics of social interactions, aggressions, and hierarchy and the individual reward learning and impulsivity through different integrated modules.

Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span

Tobias Banaschewski Thomas Frodl Sabine Herpertz Andreas Reif Christine Margarete Freitag Ute Habel Kerstin Konrad Christiane Licht Christina Neczewicz Celina Müller Service project RWTH Aachen Central Institute of Mental Health Heidelberg University Goethe University Frankfurt Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

The central recruitment platform for collecting and curating a longitudinal dataset for studying individual aggression dynamics related to the neural, cognitive-emotional, neurobiological, psychopathological and environmental factors in patient groups.

Q02: Data management for computational modelling

Michael Hanke Gabriele Ende Richard Nkrumah Christine Ecker Klaus Mathiak Wiebke Hennig Arezoo Taebi Service project Research Center Jülich (FZJ) Central Institute of Mental Health Goethe University Frankfurt RWTH Aachen

Data management and training platform. A decentralized data management infrastructure will help focus on developmental and therapeutic longitudinal data, training all participating researchers in the necessary skills for future use.

Q03: Integrated Research Training Group (RTG)

David Slattery Lisa Wagels Tobias Banaschewski Service project Goethe University Frankfurt RWTH Aachen Central Institute of Mental Health

Bundle all training and mentoring activities in a research training group (RTG) for the young researchers participating in this collaborative research center.

Related to this project site #

Contributors

Projects