Biological Psychiatry

A02: Kontexteffekte auf Bedrohungsverarbeitung in Abhängigkeit von Testosteronspiegeln

Katja Bertsch Sabine Herpertz Ute Habel Isabel Neumann Nick Worm Wuerzburg Heidelberg Aachen Research-Area-A Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Der Fokus liegt auf den Einflüssen eines provozierenden Kontexts auf die soziale Bedrohungsverarbeitung bei AMD unter unterschiedlichen Testosteronspiegeln.

A04: Implizite chemosensorische Bedrohungssignale als Stimulatoren von Amygdala-Hyperresponsivität bei AMD

Ute Habel Natalia Chechko Aachen Research-Area-A Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Wir nutzen bedrohungsbezogene chemosensorische Stimuli, nämlich Körpergeruch, der während aggressivem Verhalten (Boxen) erworben und unbewusst wahrgenommen wird, um erhöhte Amygdala-Reaktionen auf Bedrohungsreize bei aggressiven Patienten zu untersuchen.

A05: Verletzungen des peripersonalen Raums und soziale Bedrohung: psychologische und neuronale Mechanismen des Umweltrisikos für reaktive Aggression im Alltag

Heike Tost Andreas Meyer-Lindenberg Mannheim Research-Area-A Human Cognitive and Systems Neuroscience Biological Psychiatry

Der peripersonale Raum, die Repräsentation des Raums unmittelbar um den Körper herum, wird als zugrunde liegender Faktor für Bedrohungserleben untersucht.

A07: Die intestinale Mikrobiota als Regulator von aggressivem und impulsivem Verhalten

David Slattery Andreas Reif Frankfurt Research-Area-A Biological Psychiatry

Dieses translationale Projekt untersucht geschlechtsabhängige Verhaltenseffekte der fäkalen Mikrobiota-Transplantation von AMD-Patienten (ausgewählt basierend auf ihren aggressiven und impulsiven Merkmalen aus Q01) sowie gesunden Kontrollpersonen an mikrobiomdepletierte Mäuse.

A08: Die metabolische Lungen-Hirn-Achse bei aggressivem Verhalten bei Patienten mit AMD

Thomas Frodl David Slattery Gabriele Ende Aachen Frankfurt Mannheim Research-Area-A Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Beta-Hydroxy-Butyrat (BHB), ein Ketonkörper, ist negativ mit aggressivem Verhalten assoziiert.

B01: Neurobehavioral effects of repetitive prefrontal transcranial direct current stimulation (tDCS) on pathological aggression

Carmen Weidler Andreas Reif Aachen Frankfurt Research-Area-B Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

TDCS will be used as an interventional tool to decrease aggression.

B02: Young offenders’ self-regulation deficit as a common mechanism for aggressive behavior and psychopathology - neural mechanisms and role of adverse childhood experiences

Wolfgang Retz Oliver Tüscher Mainz Research-Area-B Cognitive, Systems and Behavioural Neurobiolog Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

This project aims to identify cognitive and emotion control deficits in the context of negative valence and threat interference and their association with ACE in young offenders.

B03: A process-based brain-computer interface to modulate aggressive behavior – a real-time fMRI neurofeedback study

Klaus Mathiak Christian Paret Jana Zweerings Aachen Mannheim Research-Area-B Biological Psychiatry

Probe the self-regulation of CS networks in adults and adolescents diagnosed with mental disorders related to frequent stress-associated affective outbursts and aggressive symptoms in posttraumatic stress disorder (PTSD), and BPD.

B04: Investigating psychological and neural correlates of intimate partner violence

Lisa Wagels Andreas Meyer-Lindenberg Katja Bertsch Julia Koch Julia Schräder Linda Wilkin-Krug Aachen Mannheim Wuerzburg Research-Area-B Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Focus on the neural correlates of characterizing cognitive control deficits during conflict situations.

C01: Gene-environment interactions and the role of impulsivity in responding to acute threats: early life stress and escalated aggression in recombinant inbred mouse strains

Aet O'Leary David Slattery Frankfurt Research-Area-C Biological Psychiatry

Sex-dependent effects and gene-environment interactions will be investigated by applying escalating aggression paradigms.

C02: Aggressive decisions in social conflicts: Neuro-cognitive models for healthy individuals and psychiatric patients with high scores of aggression

Christoph Korn Klaus Mathiak Aachen Heidelberg Research-Area-C Dfg-110-02 Cognitive, Systems and Behavioural Neurobiolog Human Cognitive and Systems Neuroscience Biological Psychiatry

Develop virtual scenarios to assess decision strategies in cartoon-like and naturalistic contexts.

C03: Distributed network control and interventions to frustrative non-reward and threat triggered aggressions

Wolfgang Kelsch Wolfgang Weber-Fahr Mainz Mannheim Research-Area-C Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Investigate context-dependent aggression triggered by frustrative non-reward or acute social threats.

C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression

Christine Margarete Freitag Andreas G Chiocchetti Frankfurt Research-Area-C Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Address sex-specific NVS (reactive aggression) and CS (different dimensions of psychopathy, proactive aggression) associated risk factors, and risk factor-based biosignatures in young people.

C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems

Christine Ecker Frankfurt Research-Area-C Biological Psychiatry

Link questionnaire measures of aggression to specific neural substrates using structural MRI.

C07: Identifying mediators of threat-aggression and experimental manipulation by tDCS

Michael Plichta Wolfgang Retz Frankfurt Mainz Research-Area-C Biological Psychiatry

Test the interaction of the CS and frustrative non-reward as part of the NVS.

Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span

Tobias Banaschewski Thomas Frodl Sabine Herpertz Andreas Reif Christine Margarete Freitag Ute Habel Kerstin Konrad Christiane Licht Christina Neczewicz Celina Müller Service-Project Aachen Mannheim Heidelberg Frankfurt Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

The central recruitment platform for collecting and curating a longitudinal dataset for studying individual aggression dynamics related to the neural, cognitive-emotional, neurobiological, psychopathological and environmental factors in patient groups.

Projects