Frankfurt

A07: Die intestinale Mikrobiota als Regulator von aggressivem und impulsivem Verhalten

David Slattery Andreas Reif Frankfurt Research-Area-A Biological Psychiatry

Dieses translationale Projekt untersucht geschlechtsabhängige Verhaltenseffekte der fäkalen Mikrobiota-Transplantation von AMD-Patienten (ausgewählt basierend auf ihren aggressiven und impulsiven Merkmalen aus Q01) sowie gesunden Kontrollpersonen an mikrobiomdepletierte Mäuse.

A08: Die metabolische Lungen-Hirn-Achse bei aggressivem Verhalten bei Patienten mit AMD

Thomas Frodl David Slattery Gabriele Ende Aachen Frankfurt Mannheim Research-Area-A Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Beta-Hydroxy-Butyrat (BHB), ein Ketonkörper, ist negativ mit aggressivem Verhalten assoziiert.

B01: Neurobehavioral effects of repetitive prefrontal transcranial direct current stimulation (tDCS) on pathological aggression

Carmen Weidler Andreas Reif Aachen Frankfurt Research-Area-B Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

TDCS will be used as an interventional tool to decrease aggression.

C01: Gene-environment interactions and the role of impulsivity in responding to acute threats: early life stress and escalated aggression in recombinant inbred mouse strains

Aet O'Leary David Slattery Frankfurt Research-Area-C Biological Psychiatry

Sex-dependent effects and gene-environment interactions will be investigated by applying escalating aggression paradigms.

C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression

Christine Margarete Freitag Andreas G Chiocchetti Frankfurt Research-Area-C Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

Address sex-specific NVS (reactive aggression) and CS (different dimensions of psychopathy, proactive aggression) associated risk factors, and risk factor-based biosignatures in young people.

C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems

Christine Ecker Frankfurt Research-Area-C Biological Psychiatry

Link questionnaire measures of aggression to specific neural substrates using structural MRI.

C07: Identifying mediators of threat-aggression and experimental manipulation by tDCS

Michael Plichta Wolfgang Retz Frankfurt Mainz Research-Area-C Biological Psychiatry

Test the interaction of the CS and frustrative non-reward as part of the NVS.

Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span

Tobias Banaschewski Thomas Frodl Sabine Herpertz Andreas Reif Christine Margarete Freitag Ute Habel Kerstin Konrad Christiane Licht Christina Neczewicz Celina Müller Service-Project Aachen Mannheim Heidelberg Frankfurt Biological Psychiatry Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry

The central recruitment platform for collecting and curating a longitudinal dataset for studying individual aggression dynamics related to the neural, cognitive-emotional, neurobiological, psychopathological and environmental factors in patient groups.

Q02: Data management for computational modelling

Michael Hanke Gabriele Ende Richard Nkrumah Christine Ecker Klaus Mathiak Wiebke Hennig Arezoo Taebi Service-Project Juelich Mannheim Frankfurt Aachen

Data management and training platform.

Q03: Integrated Research Training Group (RTG)

David Slattery Lisa Wagels Tobias Banaschewski Service-Project Frankfurt Aachen Mannheim

Bundle all training and mentoring activities in a research training group (RTG) for the young researchers participating in this collaborative research center.

Projects